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desvenlafaxine will enhance the level or outcome of codeine by affecting hepatic enzyme CYP2D6 metabolism. Use Caution/Watch. Desvenlafaxine inhibits CYP2D6; with larger desvenlafaxine doses (ie, 400 mg) decrease the CYP2D6 substrate dose by approximately fifty%; no dosage adjustment required with desvenlafaxine doses seven consecutive days right a